A pH-responsive biomimetic drug delivery nanosystem for targeted chemo-photothermal therapy of tumors

Smart drug delivery nanosystem is significant for tumor treatments due to its possibility of temporally, spatially, and dose-controlled release. However, the therapeutic efficacy often compromised in cancer treatment as enrichment agents reticuloendothelial system. Herein, doxorubicin (DOX) loaded biomimetic with macrophage cell membrane (MCM) camouflaged, MnFe2O4-DOX-MCM nanocube (NC), developed targeting, pH-stimuli release, chemo-photothermal effects. The shows capability immune escape enhanced cellular uptake cells MCM decoration. Acid-labile bond between MnFe2O4 NCs DOX remains stable at physiological condition release drugs immediately response endo-/lysosome pH stimuli. Meanwhile, photothermal effect destroys tissue, which further promotes chemotherapeutic efficacy. In vivo results demonstrate homing ability produce a notable synergistic NCs. Thus, pH-responsive nanosystem, NCs, an effective nanoplatform, might be potential application treatment.